Detection of doxorubicin hydrochloride accumulation in the rat brain after morphine treatment by mass spectrometry
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study of cohesive devices in the textbook of english for the students of apsychology by rastegarpour
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According to some studies, the number of addicted females in reproductive ages has been increased. The present study was designed to investigate the effect of oral morphine consumption on the development of CNS and body growth in rats. For this purpose, female Sprauge-Dawley rats were divided into control and experimental groups (20 animals in each group). Maintenance dose of morphine (0/4 mg/m...
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The possibility of chemical modification of peptides and proteins under the condition of proteolytic digestions and FABMS analysis was investigated. The results ;indicate that among the amino acid constituents of peptides and proteins: serinefcysteine, and cystine are the most sensitive residues which undergo chemical modificadons under the exprimenta1 conditions. The chemical modification ...
متن کاملDirect analysis of neuropeptides by in situ MALDI-TOF mass spectrometry in the rat brain.
The measure of neuropeptides is an important tool in biology to better define endocrine and neuroendocrine function. Traditionally most methods have relied on the development of specific antibodies. Newer molecular methodologies have used measures of gene expression of neuropeptide precursors, such as Northern blot, PCR or in situ hybridization analysis. Matrix-assisted laser desorption/ionizat...
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ژورنال
عنوان ژورنال: Cancer Chemotherapy and Pharmacology
سال: 2010
ISSN: 0344-5704,1432-0843
DOI: 10.1007/s00280-010-1429-3